ノンコーディングRNA in 比較病態解析 獣医医療でのマイクロRNA解析

鹿児島大学共同獣医学部 三浦研究室

類似点と相違点に着目して比較することで,動物と人のより良い未来の医療へ!!

トピックスTopics

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研究背景Research

比較病態解析の概念の元、いろんな動物種の疾患と人の疾患を、non-coding RNAやSNPsなどをターゲットに解析しています.興味のある方は、是非、一緒に研究しましょう。

関連業績Achievement

論文発表成果(研究室主催 三浦がCorresponding author :*、Equal contributiion: **)

  1. Iwanaga T, Fukushima R, Nagasato T, Maruyama I, Miura N*: Analysis of blood clotting with the total thrombus analysis system in healthy dogs. J Vet Diagn Invest 2021: In press 1040638721991862
  2. Nakatomi K, Ueno H, Ishikawa Y, Salim RC, Mori Y, Kanemoto I, Tancharoen S, Kikuchi K, Miura N, Omori TOkuda-Ashitaka E, Matsumura K, Imaizumi H, Motomiya Y, Maruyama I, Kawahara KI: TLR4/MD-2 is a receptor for extracellular nucleophosmin 1. Biomed Rep 2021: 14(1): 21
  3. Ijiri M, Lai YC, Kawaguchi H, Fujimoto Y, Miura N,Matsuo T, Tanimoto A:  NR6A1 Allelic Frequencies as an Index for both Miniaturizing and Increasing Pig Body Size. In Vivo 2021, 35(1): 163-167.
  4. Lai YC, Habiby GH, Jasing Pathiranage CC, Rahman MM, Chen HW, Husna AA, Kubota C, Miura N*: Bovine serum miR-21 expression affected by mastitis. Res Vet Sci 2020, In press
  5. Yoshimura A, Ohmori T, Yamada S, Kawaguchi T, Kishimoto M, Iwanaga T, Miura N, Fukushima R: Comparison of pancreatic and renal blood flow in a canine tachycardia-induced cardiomyopathy model. J Vet Med Sci 2020, 82(6):836-845.PubMED
  6. Yamazaki H, Tanaka T, Mie K, Nishida H, Miura N, Akiyoshi H: Assessment of postoperative adjuvant treatment using toceranib phosphate against adenocarcinoma in dogs. J Vet Intern Med 2020, 34(3):1272-1281.
  7. Rahman MM, Lai YC, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Hatai H, Miyoshi N, Nakagawa T, Fukushima R, Miura N*,: Aberrantly expressed snoRNA, snRNA, piRNA and tRFs in canine melanoma. Veterinary and comparative oncology 2020, 18(3):353-361.
  8. Rahman MM, Lai YC, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Hatai H, Miyoshi N, Nakagawa T, Fukushima R, Miura N*: Transcriptome analysis of dog oral melanoma and its oncogenic analogy with human melanoma. Oncol Rep 2020, 43(1):16-30.
  9. Lai YC, Lai YT, Rahman MM, Chen HW, Husna AA, Fujikawa T, Ando T, Kitahara G, Koiwa M, Kubota C, Miura N*: Bovine milk transcriptome analysis reveals microRNAs and RNU2 involved in mastitis. FEBS J 2020, 287(9):1899-1918.
  10. Kake S, Kawaguchi H, Nagasato T, Yamada T, Ito T, Maruyama I, Miura N*, Tanimoto A: Association Between HMGB1 and Thrombogenesis in a Hyperlipaemia-induced Microminipig Model of Atherosclerosis. In Vivo 2020, 34(4):1871-1874.
  11. Iwanaga T, Miura N, Brainard BM, Brooks MB, Goggs R: A Novel Microchip Flow Chamber (Total Thrombus Analysis System) to Assess Canine Hemostasis. Front Vet Sci 2020, 7:307.
  12. Yamada S, Hirao D, Miura N, Iwanaga T, Kawaguchi T, Yoshimura A, Oomori T, Nagasato T, Maruyama I, Fukushima R: Comparison between blood coagulability in the intra-atrial and peripheral regions during the acute phase after rapid atrial pacing. Exp Anim 2019, 68(2):137-146.
  13. Ushio N, Rahman MM, Maemura T, Lai YC, Iwanaga T, Kawaguchi H, Miyoshi N, Momoi Y, Miura N*: Identification of dysregulated microRNAs in canine malignant melanoma. Oncol Lett 2019, 17(1):1080-1088.
  14. Rahman MM, Lai YC, Husna AA, Chen HW, Tanaka Y, Kawaguchi H, Miyoshi N, Nakagawa T, Fukushima R, Miura N*: Micro RNA Transcriptome Profile in Canine Oral Melanoma. Int J Mol Sci 2019, 20(19).
  15. Kawaguchi H, Horie M, Onoue K, Noguchi M, Akioka K, Masatani T, Miura N, Ozawa M, Tanimoto A: Development of a Model of Porcine Epidemic Diarrhea in Microminipigs. Vet Pathol 2019, 56(5):711-714.
  16. Yamada S, Hirao D, Miura N, Iwanaga T, Kawaguchi T, Yoshimura A, Oomori T, Nagasato T, Maruyama I, Fukushima R: Comparison of chronological changes in blood characteristics in the atrium and peripheral vessels after the development of non-valvular atrial fibrillation. Thromb Res 2018, 171:31-37.
  17. Rahman MM, Amin KB, Rahman SMM, Khair A, Rahman M, Hossain A, Rahman A, Parvez MS, Miura N*, Alam MM: Investigation of methicillin-resistant Staphylococcus aureus among clinical isolates from humans and animals by culture methods and multiplex PCR. BMC Vet Res 2018, 14(1):300.
  18. Lai YC, Ushio N, Rahman MM, Katanoda Y, Ogihara K, Naya Y, Moriyama A, Iwanaga T, Saitoh Y, Sogawa T,Miura N* et al: Aberrant expression of microRNAs and the miR-1/MET pathway in canine hepatocellular carcinoma. Veterinary and comparative oncology 2018, 16(2):288-296.
  19. Kakihana Y, Kamikokuryo C, Furubeppu H, Madokoro Y, Futatsuki T, Miyamoto S, Haraura H, Hatanaka K, Eguchi T, Saitoh Y, Miura N, et al: Monitoring of Brain Oxygenation During and After Cardiopulmonary Resuscitation: A Prospective Porcine Study. Adv Exp Med Biol 2018, 1072:83-87.
  20. Abe M, Kawaguchi H, Miura N, Akioka K, Ushikai M, Oi S, Yukawa A, Yoshikawa T, Izumi H, Horiuchi M: Diurnal Variation of Melatonin Concentration in the Cerebrospinal Fluid of Unanesthetized Microminipig. In Vivo 2018, 32(3):583-590.
  21. Zahorul Islam M, Kawaguchi H, Miura N*, Miyoshi N, Yamazaki-Himeno E, Shiraishi M, Miyamoto A, Tanimoto A: Hypertension alters the endothelial-dependent biphasic response of bradykinin in isolated Microminipig basilar artery. Microvasc Res 2017, 114:52-57.
  22. Yamazaki H, Miura N, Lai YC, Takahashi M, Goto-Koshino Y, Yasuyuki M, Nakaichi M, Tsujimoto H, Setoguchi A, Endo Y: Effects of toceranib phosphate (Palladia) monotherapy on multidrug resistant lymphoma in dogs. J Vet Med Sci 2017, 79(7):1225-1229.
  23. Yamazaki H, Lai YC, Tateno M, Setoguchi A, Goto-Koshino Y, Endo Y, Nakaichi M, Tsujimoto H, Miura N*: Hypoxia-activated prodrug TH-302 decreased survival rate of canine lymphoma cells under hypoxic condition. PLoS One 2017, 12(5):e0177305.
  24. Yamada S, Kawaguchi H, Yamada T, Guo X, Matsuo K, Hamada T, Miura N, Tasaki T, Tanimoto A: Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and Nonalcoholic Fatty Liver Disease in Microminipigs. J Atheroscler Thromb 2017, 24(11):1150-1166.
  25. Lai YC, Fujikawa T, Maemura T, Ando T, Kitahara G, Endo Y, Yamato O, Koiwa M, Kubota C, Miura N*: Inflammation-related microRNA expression level in the bovine milk is affected by mastitis. PLoS One 2017, 12(5):e0177182.
  26. Lai YC, Fujikawa T, Ando T, Kitahara G, Koiwa M, Kubota C, Miura N*: Rapid Communication: MiR-92a as a housekeeping gene for analysis of bovine mastitis-related microRNA in milk. J Anim Sci 2017, 95(6):2732-2735.
  27. Kikuchi K, Setoyama K, Kawahara KI, Nagasato T, Terashi T, Ueda K, Nakanishi K, Otsuka S, Miura N*, Sameshima H et al: Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis. Oxid Med Cell Longev 2017, 2017:6873281.
  28. Morishita S, Kawaguchi H, Ono T, Miura N, Murakoshi M, Sugiyama K, Kato H, Tanimoto A, Nishino H: Enteric lactoferrin attenuates the development of high-fat and high-cholesterol diet-induced hypercholesterolemia and atherosclerosis in Microminipigs. Biosci Biotechnol Biochem 2016, 80(2):295-303.
  29. Hosokawa K, Ohnishi-Wada T, Sameshima-Kaneko H, Nagasato T, Miura N, Kikuchi K, Koide T, Maruyama I, Urano T: Plasminogen activator inhibitor type 1 in platelets induces thrombogenicity by increasing thrombolysis resistance under shear stress in an in-vitro flow chamber model. Thromb Res 2016, 146:69-75.
  30. Otomaru K, Fujikawa T, Saito Y, Ando T, Obi T, Miura N, Kubota C: Diagnostic imaging of intra-abdominal cyst in heifer using the computed tomography. J Vet Med Sci 2015, 77(9):1191-1193.
  31. Noguchi M, Miura N, Ando T, Kubota C, Hobo S, Kawaguchi H, Tanimoto A: Profiles of reproductive hormone in the microminipig during the normal estrous cycle. In Vivo 2015, 29(1):17-22.
  32. Kohyama M, Yabuki A, Kawasaki Y, Kawaguchi H, Miura N, Kitano Y, Onitsuka T, Rahman MM, Miyoshi N, Yamato O: GM2 Gangliosidosis Variant 0 (Sandhoff Disease) in a Mixed-Breed Dog. J Am Anim Hosp Assoc 2015, 51(6):396-400.
  33. Murata D, Sogawa T, Tokunaga S, Iwanaga T, Kawaguchi H, Miyoshi N, Momoi Y, Fujiki M, Miura N*: Ganglion cysts arising from a canine stifle joint. J Vet Med Sci 2014, 76(3):457-459.
  34. Murata D, Miyakoshi D, Hatazoe T, Miura N, Tokunaga S, Fujiki M, Nakayama K, Misumi K: Multipotency of equine mesenchymal stem cells derived from synovial fluid. Vet J 2014, 202(1):53-61.
  35. Miura N, Kucho K, Noguchi M, Miyoshi N, Uchiumi T, Kawaguchi H, Tanimoto A: Comparison of the genomic sequence of the microminipig, a novel breed of swine, with the genomic database for conventional pig. In Vivo 2014, 28(6):1107-1111.
  36. Kawaguchi H, Yamada T, Miura N, Ayaori M, Uto-Kondo H, Ikegawa M, Noguchi M, Wang KY, Izumi H, Tanimoto A: Rapid development of atherosclerosis in the world's smallest Microminipig fed a high-fat/high-cholesterol diet. J Atheroscler Thromb 2014, 21(3):186-203.
  37. Hosokawa K, Ohnishi T, Sameshima H, Miura N, Koide T, Maruyama I, Tanaka KA: Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model. PLoS One 2014, 9(1):e86491.
  38. Hosokawa K, Ohnishi T, Miura N, Sameshima H, Koide T, Tanaka KA, Maruyama I: Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions. Thromb Res 2014, 133(1):66-72.
  39. Akioka K, Kawaguchi H, Kitajima S, Miura N, Noguchi M, Horiuchi M, Miyoshi N, Tanimoto A: Investigation of necessity of sodium cholate and minimal required amount of cholesterol for dietary induction of atherosclerosis in microminipigs. In Vivo 2014, 28(1):81-90.
  40. Yoshikawa T, Takahashi Y, Kawaguchi H, Utsunomiya S, Miura N, Izumi H, Miyoshi N, Tanimoto A: A dermal phototoxicity study following intravenous infusion administration of ciprofloxacin hydrochloride in the novel microminipigs. Toxicol Pathol 2013, 41(1):109-113.
  41. Tasaki Y, Miura N, Iyori K, Nishifuji K, Endo Y, Momoi Y: Generalized alopecia with vasculitis-like changes in a dog with babesiosis. J Vet Med Sci 2013, 75(10):1367-1369.
  42. Miura N, Kawaguchi H, Nagasato T, Yamada T, Ito T, Izumi H, Shameshima H, Miyoshi N, Tanimoto A, Maruyama I: Coagulation activity and white thrombus formation in the microminipig. In Vivo 2013, 27(3):357-361.
  43. Miura N, Furukawa M, Magari Y, Momoi Y: Cross-reactivity of the anti-human D-dimer monoclonal antibody 1C9-6F10 to canine fibrin degradation products. J Vet Med Sci 2013, 75(7):963-966.
  44. Kikuchi K, Tancharoen S, Ito T, Morimoto-Yamashita Y, Miura N, Kawahara K, Maruyama I, Murai Y, Tanaka E: Potential of the angiotensin receptor blockers (ARBs) telmisartan, irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke. Int J Mol Sci 2013, 14(9):18899-18924.
  45. Kikuchi K, Miura N, Kawahara KI, Murai Y, Morioka M, Lapchak PA, Tanaka E: Edaravone (Radicut), a free radical scavenger, is a potentially useful addition to thrombolytic therapy in patients with acute ischemic stroke. Biomed Rep 2013, 1(1):7-12.
  46. Kawaguchi H, Yamada T, Miura N, Noguchi M, Izumi H, Miyoshi N, Tanimoto A: Sex differences of serum lipid profile in novel microminipigs. In Vivo 2013, 27(5):617-621.
  47. Hosokawa K, Ohnishi T, Sameshima H, Miura N, Ito T, Koide T, Maruyama I: Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions. Thromb Haemost 2013, 109(1):102-111.
  48. Murata D, Miura N*, Iwanaga T, Tokunaga S, Miyoshi N, Kitano Y, Momoi Y, Fujiki M: CT and MRI imaging diagnosis of epidural idiopathic sterile pyogranulomatous inflammation in a dog spinal canal. J Vet Med Sci 2012, 74(7):913-915.
  49. Kikuchi K, Takeshige N, Miura N, Morimoto Y, Ito T, Tancharoen S, Miyata K, Kikuchi C, Iida N, Uchikado H et al: Beyond free radical scavenging: Beneficial effects of edaravone (Radicut) in various diseases (Review). Experimental and therapeutic medicine 2012, 3(1):3-8.
  50. Kikuchi K, Kawahara KI, Miura N, Ito T, Morimoto Y, Tancharoen S, Takeshige N, Uchikado H, Sakamoto R, Miyagi N et al: Secondary prevention of stroke: Pleiotropic effects of optimal oral pharmacotherapy. Experimental and therapeutic medicine 2012, 4(1):3-7.
  51. Kawaguchi H, Yamada T, Miura N, Takahashi Y, Yoshikawa T, Izumi H, Kawarasaki T, Miyoshi N, Tanimoto A: Reference values of hematological and biochemical parameters for the world smallest microminipigs. J Vet Med Sci 2012, 74(7):933-936.
  52. Iwanaga T, Miura N, Miyoshi N, Endo Y, Momoi Y: Abnormal erythroid cell proliferation and myelofibrosis in a cat. J Vet Med Sci 2012, 74(7):909-912.
  53. Meng X, Kawahara KI, Miyanohara H, Yoshimoto Y, Yoshinaga K, Noma S, Kikuchi K, Morimoto Y, Ito T, Oyama Y et al: 1,5-Anhydro-D-fructose: A natural antibiotic that inhibits the growth of gram-positive bacteria and microbial biofilm formation to prevent nosocomial infection. Experimental and therapeutic medicine 2011, 2(4):625-628.
  54. Kikuchi K, Uchikado H, Miyagi N, Morimoto Y, Ito T, Tancharoen S, Miura N, Miyata K, Sakamoto R, Kikuchi C et al: Beyond neurological disease: new targets for edaravone (Review). Int J Mol Med 2011, 28(6):899-906.
  55. Kikuchi K, Uchikado H, Miura N, Morimoto Y, Ito T, Tancharoen S, Miyata K, Sakamoto R, Kikuchi C, Iida N et al: HMGB1 as a therapeutic target in spinal cord injury: A hypothesis for novel therapy development. Experimental and therapeutic medicine 2011, 2(5):767-770.
  56. Kikuchi K, Kawahara KI, Uchikado H, Miyagi N, Kuramoto T, Miyagi T, Morimoto Y, Ito T, Tancharoen S, Miura N et al: Potential of edaravone for neuroprotection in neurologic diseases that do not involve cerebral infarction. Experimental and therapeutic medicine 2011, 2(5):771-775.
  57. Kawaguchi H, Miyoshi N, Miura N, Horiuchi M, Ono T, Murakoshi M, Nishino H, Nagata R, Sahara H, Tanimoto A et al: Microminipig: research models to break through cardiovascular disease. Journal of pharmacological sciences 2011, 115:49P-49P.
  58. Kawaguchi H, Miyoshi N, Miura N, Fujiki M, Horiuchi M, Izumi Y, Miyajima H, Nagata R, Misumi K, Takeuchi T et al: Microminipig, a non-rodent experimental animal optimized for life science research:novel atherosclerosis model induced by high fat and cholesterol diet. Journal of pharmacological sciences 2011, 115(2):115-121.
  59. Shrestha B, Hashiguchi T, Ito T, Miura N**, Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki IY, Arimura N et al: B cell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes. J Immunol 2010, 184(9):4819-4826.
  60. Miyoshi N, Horiuchi M, Inokuchi Y, Miyamoto Y, Miura N, Tokunaga S, Fujiki M, Izumi Y, Miyajima H, Nagata R et al: Novel microminipig model of atherosclerosis by high fat and high cholesterol diet, established in Japan. In Vivo 2010, 24(5):671-680.
  61. Kikuchi K, Kawahara KI, Biswas KK, Ito T, Tancharoen S, Shiomi N, Koda Y, Matsuda F, Morimoto Y, Oyama Y et al: HMGB1: A new marker for estimation of the postmortem interval. Experimental and therapeutic medicine 2010, 1(1):109-111.
  62. Kikuchi K, Kawahara K-I, Tsuji C, Tajima Y, Kuramoto T, Shihara M, Koga Y, Shiomi N, Uchikado H, Morimoto Y et al: Post mortem contrast-enhanced computed tomography in a case of sudden death from acute pulmonary thromboembolism. Experimental and therapeutic medicine 2010, 1(3):503-505.
  63. Kikuchi K, Kawahara K, Miyagi N, Uchikado H, Kuramoto T, Morimoto Y, Tancharoen S, Miura N, Takenouchi K, Oyama Y et al: Edaravone: a new therapeutic approach for the treatment of acute stroke. Medical hypotheses 2010, 75(6):583-585.
  64. Kawaguchi H, Miyoshi N, Fujiki M, Miura N, Horiuchi M, Itoh K, Kaneko N, Miyajima H, Nagata R, Misumi K et al: Microminipig atherosclerosis model by high fat and cholesterol-diet. Journal of pharmacological sciences 2010, 112:34P-34P.
  65. Meng X, Kawahara K, Nawa Y, Miura N, Shrestha B, Tancharoen S, Sameshima H, Hashiguchi T, Maruyama I: 1,5-Anhydro-D-fructose attenuates lipopolysaccharide-induced cytokine release via suppression of NF-kappaB p65 phosphorylation. Biochem Biophys Res Commun 2009, 380(2):343-348.
  66. Kikuchi K, Tancharoen S, Matsuda F, Biswas KK, Ito T, Morimoto Y, Oyama Y, Takenouchi K, Miura N, Arimura N et al: Edaravone attenuates cerebral ischemic injury by suppressing aquaporin-4. Biochem Biophys Res Commun 2009, 390(4):1121-1125.
  67. Kikuchi K, Kawahara K, Tancharoen S, Matsuda F, Morimoto Y, Ito T, Biswas KK, Takenouchi K, Miura N, Oyama Y et al: The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells. The Journal of pharmacology and experimental therapeutics 2009, 329(3):865-874.
  68. Kikuchi K, Kawahara K, Biswas KK, Ito T, Tancharoen S, Morimoto Y, Matsuda F, Oyama Y, Takenouchi K, Miura N et al: Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells. Biochem Biophys Res Commun 2009, 385(2):132-136.
  69. Kawahara K, Hashiguchi T, Masuda K, Saniabadi AR, Kikuchi K, Tancharoen S, Ito T, Miura N, Morimoto Y, Biswas KK et al: Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc. Int J Mol Med 2009, 23(5):615-620.
  70. Kawahara K, Hashiguchi T, Kikuchi K, Tancharoen S, Miura N, Ito T, Oyama Y, Nawa Y, Biswas KK, Meng X et al: Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells. Int J Mol Med 2008, 22(5):639-644.
  71. Kawahara K, Biswas KK, Unoshima M, Ito T, Kikuchi K, Morimoto Y, Iwata M, Tancharoen S, Oyama Y, Takenouchi K et al: C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells. Cardiovasc Pathol 2008, 17(3):129-138.
  72. Steffey MA, Miura N, Todhunter RJ, Nykamp SG, Freeman KP, Scarpino V, Vernier-Singer MA, Erb HN, MacLeod JN, Lust G et al: The potential and limitations of cartilage-specific (V+C)(-) fibronectin and cartilage oligomeric matrix protein as osteoarthritis biomarkers in canine synovial fluid. Osteoarthritis Cartilage 2004, 12(10):818-825.
  73. Miura N*, Fujiki M, Miyoshi Y, Misumi K, Sakamoto H: Steroid injection therapy in a feline solitary bone cyst. J Vet Med Sci 2003, 65(4):523-525. PubMED
  74. Miura N*, Fujiki M, Misumi K, Setoyama K, Takegawa K, Takahashi T, Miyahara K, Sakamoto H: Successful use of an acceleration rate response pacemaker with a transvenous steroid-eluting screw-in lead for third-degree atrioventricular block in a labrador retriever. J Vet Med Sci 2003, 65(10):1101-1105.
  75. Kamimura R, Miura N, Suzuki S: The hemodynamic effects of acute myocardial ischemia and reperfusion in Clawn miniature pigs. Exp Anim 2003, 52(4):335-338.
  76. Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zhang L, Ikeda R et al: Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes & development 2003, 17(19):2436-2449.
  77. Setoyama K, Ota H, Miura N, Fujiki M, Misumi K, Sakamoto H: Effects of milrinone on hemodynamics and regional blood flow in the hypoxic dog. J Vet Med Sci 2002, 64(6):499-503.
  78. Kawabata H, Kawahara K, Kanekura T, Araya N, Daitoku H, Hatta M, Miura N, Fukamizu A, Kanzaki T, Maruyama I et al: Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium-induced keratinocyte differentiation. J Biol Chem 2002, 277(10):8099-8105.
  79. Kamimura R, Suzuki S, Miura N, Miyahara K: Pulmonary atherosclerosis and pulmonary arterial pressure in cholesterol-fed New Zealand white rabbits. J Vet Med Sci 2001, 63(6):647-653.
  80. Misumi K, Tateno O, Fujiki M, Miura N, Sakamoto H: The risk of contrast media-induced ventricular fibrillation is low in canine coronary arteriography with ioxilan. J Vet Med Sci 2000, 62(4):421-426.
  81. Misumi K, Fujiki M, Miura N, Sakamoto H: Uterine horn torsion in two non-gravid bitches. J Small Anim Pract 2000, 41(10):468-471.
  82. Kakura H, Miyahara K, Amitani S, Sohara H, Koga M, Sakamoto H, Misumi K, Miura N: Hemodynamic effects of intravenous administration of olprinone hydrochloride on experimental pulmonary hypertension. Arzneimittelforschung 2000, 50(6):515-519.
  83. Miura N*, Suzuki S, Hamada Y, Kamimura R, Fujiki M, Misumi K, Sakamoto H: Salt water promotes hypertension in Dahl-S rats. Exp Anim 1999, 48(4):289-292.
  84. Kamimura R, Suzuki S, Sakamoto H, Miura N, Misumi K, Miyahara K: Development of atherosclerotic lesions in cholesterol-loaded rabbits. Exp Anim 1999, 48(1):1-7.
  85. Amitani S, Miyahara K, Sohara H, Kakura H, Koga M, Moriyama Y, Taira A, Nagano S, Miura N, Misumi K et al: Experimental His-bundle pacing: histopathological and electrophysiological examination. Pacing Clin Electrophysiol 1999, 22(4 Pt 1):562-566.
  86. Sakamoto H, Kirihara H, Fujiki M, Miura N, Misumi K: The effects of medetomidine on maternal and fetal cardiovascular and pulmonary function, intrauterine pressure and uterine blood flow in pregnant goats. Exp Anim 1997, 46(1):67-73.
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